A number of pathogens induce immature dendritic cells (iDC) to migrate to lymphoid organs
where, as mature DC (mDC), they serve as efficient APC. We hypothesized that pathogen …

Background It has been thought that Clostridium difficile infection is transmitted predominantly
within health care settings. However, endemic spread has hampered identification of …

The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …

We questioned the significance of haplotype structure in gene regulation by testing whether
individual single nucleotide polymorphisms (SNPs) within a gene promoter region […

Routine full characterization of Mycobacterium tuberculosis is culture based, taking many
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …

Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of
many cellular responses. We describe here human tribbles homologues (Htrbs) that control …

Background The control of Clostridium difficile infections is an international clinical challenge.
The incidence of C difficile in England declined by roughly 80% after 2006, following the …

Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are
mostly focused on well-studied merozoite antigens that induce immune responses after …

Objective To determine the incidence of methicillin resistant and methicillin sensitive
Staphylococcus aureus (MRSA and MSSA) bacteraemia in inpatients and associated mortality …

Background. Despite substantial interest in biomarkers, their impact on clinical outcomes
and variation with bacterial strain has rarely been explored using integrated databases. …