Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical
features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin …

The hemoglobin molecule is a tetramer consisting of 2 pairs of globin chains, each of which
contains a heme group. During fetal development, the major hemoglobin is Hb F (2 2). In a …

HYDROPS FETALIS is a serious disorder, usually indica-tive of an ominous prognosis for the
affected fetus. There are many causes, including both hereditary and acquired diseases. 1-…

We have constructed a relational database of hemoglobin variants and thalassemia mutations,
called HbVar, which can be accessed on the web at http://globin. cse. psu. edu. Extensive …

The discovery of the presence of fetal DMA in maternal plasma has provided a new approach
for non-invasive prenatal diagnosis. At present, the prenatal diagnosis of p thalassaemia …

HbVar ( http://globin.cse.psu.edu/globin/hbvar/ ) is a relational database developed by a
multi‐center academic effort to provide up‐to‐date and high quality information on the genomic …

Background The thalassemias are common in southern China. We determined the prevalence
of heterozygous carriers of these genetic disorders in Hong Kong and assessed the …

The analysis of circulating nucleic acids has revealed applications in the noninvasive
diagnosis, monitoring, and prognostication of many clinical conditions. Circulating fetal-specific …

HbVar ( http://globin.bx.psu.edu/hbvar ) is a locus‐specific database (LSDB) developed in
2001 by a multi‐center academic effort to provide timely information on the genomic sequence …

Fetal hemoglobin (HbF) modulates the phenotype of sickle cell anemia by inhibiting deoxy
sickle hemoglobin (HbS) polymerization. The blood concentration of HbF, or the number of …