Study Design. A retrospective cohort study was conducted in 5573 female patients with
scoliosis who were referred for treatment at 14 orthopedic medical centers in the United States. …

Background: To evaluate hypotheses about the relationship between immune alterations and
cancer, several investigators have determined cancer incidence in groups of patients with …

The expansion of the biologics pipeline depends on the identification of candidate proteins
for clinical trials. Speed is one of the critical issues, and the rapid production of high quality, …

Cancer incidence was ascertained in a population-based cohort of 51,008 patients in
Uppsala, Sweden, who were given a discharge diagnosis of diabetes mellitus during 1965–83. …

DNA sequence variation has been associated with quantitative changes in molecular
phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody responses
to the spike (S) protein monomer, S protein native trimeric form, or the nucleocapsid (N) …

Background Cognitive behavioural therapy (CBT) is now a recommended treatment for
people with schizophrenia. This approach helps to link the person's distress and problem …

Various DNA methyl transferase inhibitors (iDNMTs) and histone deacetylase inhibitors (iHDACs)
were screened for their ability to enhance transient gene expression (TGE) in Human …

Chromatin state variation at gene regulatory elements is abundant across individuals, yet we
understand little about the genetic basis of this variability. Here, we profiled several histone …

The purpose of this review is to describe the current status and to highlight several emerging
trends in the manufacture of recombinant therapeutic proteins in cultivated mammalian cells…