User profiles for David J Clark

David Clark

- Verified email at stanford.edu - Cited by 10085

David J. Clark

- Verified email at ufl.edu - Cited by 5808

David J Clark

- Verified email at astrazeneca.com - Cited by 4795

[PDF][PDF] Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

…, J Day, J Suh, JR Whiteaker, J Eschbacher, J McGee… - Cell, 2020 - cell.com
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and …

Inverted electron-hole alignment in InAs-GaAs self-assembled quantum dots

…, M Al-Khafaji, JPR David, AG Cullis, G Hill, JC Clark - Physical review …, 2000 - APS
New information on the electron-hole wave functions in InAs-GaAs self-assembled quantum
dots is deduced from Stark effect spectroscopy. Most unexpectedly it is shown that the hole …

[PDF][PDF] Proteogenomic characterization of pancreatic ductal adenocarcinoma

…, DC Zhou, Y Hu, TM Lih, SR Savage, K Krug, DJ Clark… - Cell, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Merging of healthy motor modules predicts reduced locomotor performance and muscle coordination complexity post-stroke

DJ Clark, LH Ting, FE Zajac… - Journal of …, 2010 - journals.physiology.org
Evidence suggests that the nervous system controls motor tasks using a low-dimensional
modular organization of muscle activation. However, it is not clear if such an organization …

Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal

MS Angst, W Koppert, I Pahl, DJ Clark, M Schmelz - Pain, 2003 - Elsevier
Numerous animal studies suggest that acute and chronic exposure to opioids can be
associated with the development of hyperalgesia, ie an increased sensitivity to noxious stimuli. …

[PDF][PDF] Integrated proteogenomic characterization of clear cell renal cell carcinoma

DJ Clark, SM Dhanasekaran, F Petralia, J Pan, X Song… - Cell, 2019 - cell.com
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC),
we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and …

[HTML][HTML] Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study

LF Chu, DJ Clark, MS Angst - The Journal of Pain, 2006 - Elsevier
There is accumulating evidence that opioid therapy might not only be associated with the
development of tolerance but also with an increased sensitivity to pain, a condition referred to …

Modular control of human walking: a simulation study

RR Neptune, DJ Clark, SA Kautz - Journal of biomechanics, 2009 - Elsevier
Recent evidence suggests that performance of complex locomotor tasks such as walking
may be accomplished using a simple underlying organization of co-active muscles, or “modules…

[PDF][PDF] Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

…, K Li, A Colaprico, QK Li, DJ Clark, Y Hu, L Cao, J Pan… - Cancer cell, 2021 - cell.com
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

[PDF][PDF] Proteogenomic and metabolomic characterization of human glioblastoma

…, DJ Clark, H Culpepper, T Czernicki, F D'Angelo, J Day… - Cancer cell, 2021 - cell.com
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its
molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of …