Background Although statins reduce coronary and cerebrovascular morbidity and mortality
in middle-aged individuals, their efficacy and safety in elderly people is not fully established. …

Background Trials of statin therapy have had conflicting findings on the risk of development
of diabetes mellitus in patients given statins. We aimed to establish by a meta-analysis of …

Background Vaccination of health-care workers has been claimed to prevent nosocomial
influenza infection of elderly patients in long-term care. Data are, however, limited on this …

Vaccination of health care workers (HCWs) is recommended as a strategy for preventing
influenza in elderly patients in long-term care. However, there have been no controlled studies …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Background Clinical use of criteria for metabolic syndrome to simultaneously predict risk of
cardiovascular disease and diabetes remains uncertain. We investigated to what extent …

Background and Purpose— Robust measures of functional outcome are required to determine
treatment effects in stroke trials. Of the various measures available, the Barthel index (BI) …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We
aimed to determine whether levothyroxine provided clinical benefits in older persons with …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this important, …