Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify
candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although …

Skeletal muscle hypertrophy is defined as an increase in muscle mass, which in the adult
animal comes as a result of an increase in the size, as opposed to the number, of pre-existing …

Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown
mechanisms 1 , 2 . The roles of two signalling pathways implicated in muscle hypertrophy on …

Formation of the neuromuscular junction depends upon reciprocal inductive interactions
between the developing nerve and muscle, resulting in the precise juxtaposition of a …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced cancer …

Atrophy of skeletal muscle is a serious consequence of numerous diseases, including cancer
and AIDS. Successful treatments for skeletal muscle atrophy could either block protein …

Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic)
and catabolic (or atrophic) processes. Previously, no link between the molecular mediators …

Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and
fusion of myoblast precursors 1 . Skeletal muscle atrophy and hypertrophy refer to changes in …

Muscle wasting accompanies aging and pathological conditions ranging from cancer,
cachexia, and diabetes to denervation and immobilization. We show that activation of NF-κB, …

Formation of neuromuscular synapses requires a series of inductive interactions between
growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition …