The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation,
although this capacity markedly diminishes after the first week of life. Neuregulin-1 (…

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes.
The neonatal mouse heart can regenerate, but only during the first week of life. Here …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading
to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are key …

In Alzheimer's disease (AD), astrocytes undergo morphological changes ranging from atrophy
to hypertrophy, but the effect of such changes at the functional level is still largely unknown…

Background Macrophages and Wnt proteins (Wnts) are independently involved in cardiac
development, response to cardiac injury, and repair. However, the role of macrophage‐…

Background: Ischemic heart diseases are leading causes of death and reduced life quality
worldwide. Although revascularization strategies significantly reduce mortality after acute …

Background Inflammation has been implicated in the initiation, progression and
manifestation of hypertensive heart disease. We sought to determine the role of monocytes/…

Background: Little is known about the potentially unfavorable effects of mesenchymal
stromal cell (MSC) activation on the heart. MSCs can respond to tissue injury by anti- or …

Background Irreversible electroporation (IRE) is a non-thermal cell ablation approach that
induces selective damage to cell membranes only. The purpose of the current study was to …

Nature-inspired nanosized formulations based on an imageable, small-sized inorganic core
scaffold, on which biomolecules are assembled to form nanobiomimetics, hold great …