The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the
mechanisms by which the cellular machinery achieves such specificity are incompletely …

The human genome contains many thousands of long noncoding RNAs (lncRNAs). While
several studies have demonstrated compelling biological and disease roles for individual …

The Monastic Order in England by Dom David Knowles was originally published in 1940
and was quickly recognised as a scholarly classic and masterpiece of historical literature. It …

This volume opens with a survey of monastic life and activities in the early Tudor period,
which throws new light on the fortunes of the Cistercian abbeys and on the influence upon the …

Antibiotics have saved countless lives and enabled the development of modern medicine over
the past 70 years. However, it is clear that the success of antibiotics might only have been …

Transcriptome-wide association studies (TWAS) integrate genome-wide association studies
(GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective…

Sequence-based variation in gene expression is a key driver of disease risk. Common
variants regulating expression in cis have been mapped in many expression quantitative trait …

" One of the many merits of this book is that it places Western scholasticism in its setting--and
this both in space and in time. Plotinus lives on, Aristotle comes back to life again, Averroes …

Noncoding variants play a central role in the genetics of complex traits, but we still lack a full
understanding of the molecular pathways through which they act. We quantified the …

We present a fast mapping-based algorithm to compute the mappability of each region of a
reference genome up to a specified number of mismatches. Knowing the mappability of a …