On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529
was announced, containing far more mutations in Spike (S) than previously reported …

In the absence of effective targeted therapies for COVID-19, optimisation of supportive care
is essential. Lung injury with features of acute respiratory distress syndrome (ARDS) appears …

Multicenter preclinical studies have been suggested as a method to improve reproducibility,
generalizability and potential clinical translation of preclinical work. In these studies, multiple …

Aims Most patients who receive implantable cardioverter defibrillators (ICDs) for primary
prevention do not receive therapy during the lifespan of the ICD, whilst up to 50% of sudden …

The cardinal feature of severe coronavirus disease 2019 (COVID-19) is acute lung injury
reminiscent of acute respiratory distress syndrome (ARDS). 1 Prone positioning is an …

Aims Optimal endovascular management of intermittent claudication (IC) remains disputed.
This systematic review and meta-analysis compares efficacy and safety outcomes for balloon …

… We thank David Koeckerling and colleagues for their correspondence calling for restrictive
… Daily transfusion of the magnitude mentioned by Koeckerling and colleagues happens …

On the 24 th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading
rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than …

Introduction Awake prone positioning (APP) might benefit patients with COVID-19 by improving
oxygenation, but it is unknown whether this improvement can be sustained with serial …

Awake prone positioning is thought to improve clinical outcomes in patients with covid-19
by modulating lung mechanics during progressive hypoxaemic respiratory failure. 1 2 The …