Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
…, CR White, DM Krzywanski… - … of Physiology-Lung …, 2009 - journals.physiology.org
More than 100 million people in the United States live in areas that exceed current ozone
air quality standards. In addition to its known pulmonary effects, environmental ozone …
air quality standards. In addition to its known pulmonary effects, environmental ozone …
Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress
DM Krzywanski, DA Dickinson, KE Iles… - Archives of biochemistry …, 2004 - Elsevier
Glutamate cysteine ligase (GCL), composed of a catalytic (GCLC) and modulatory (GCLM)
subunit, catalyzes the first step of glutathione (GSH) biosynthesis. Using 4-hydroxy-2-nonenal …
subunit, catalyzes the first step of glutathione (GSH) biosynthesis. Using 4-hydroxy-2-nonenal …
Effect of group vs. single housing on phenotypic variance in C57BL/6J mice
TR Nagy, D Krzywanski, J Li, S Meleth… - Obesity …, 2002 - Wiley Online Library
Objective: To determine if group housing affects the variance of body composition
parameters in a highly inbred mouse strain. Research Methods and Procedures: Thirty 3‐week‐old …
parameters in a highly inbred mouse strain. Research Methods and Procedures: Thirty 3‐week‐old …
[HTML][HTML] Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of …
…, JD Brand, NSR Mochel, DM Krzywanski… - Journal of Biological …, 2010 - ASBMB
Transforming growth factor β (TGF-β) stimulates reactive oxygen species (ROS) production
in various cell types, which mediates many of the effects of TGF-β. The molecular …
in various cell types, which mediates many of the effects of TGF-β. The molecular …
4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells
…, T Iwamoto, H Zhang, DM Krzywanski… - Free Radical Biology …, 2002 - Elsevier
Glutathione is the most abundant non-protein thiol in the cell, with roles in cell cycle regulation,
detoxification of xenobiotics, and maintaining the redox tone of the cell. The glutathione …
detoxification of xenobiotics, and maintaining the redox tone of the cell. The glutathione …
[HTML][HTML] Nicotinamide nucleotide transhydrogenase (NNT) regulates mitochondrial ROS and endothelial dysfunction in response to angiotensin II
Endothelial dysfunction is a critical, initiating step in the development of hypertension (HTN)
and mitochondrial reactive oxygen species (ROS) are important contributors to endothelial …
and mitochondrial reactive oxygen species (ROS) are important contributors to endothelial …
[HTML][HTML] The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics
DM Krzywanski, DR Moellering, JL Fetterman… - Laboratory …, 2011 - nature.com
While there is general agreement that cardiovascular disease (CVD) development is
influenced by a combination of genetic, environmental, and behavioral contributors, the actual …
influenced by a combination of genetic, environmental, and behavioral contributors, the actual …
Endothelial cell bioenergetics and mitochondrial DNA damage differ in humans having African or West Eurasian maternal ancestry
DM Krzywanski, DR Moellering… - Circulation …, 2016 - Am Heart Assoc
Background— We hypothesized that endothelial cells having distinct mitochondrial genetic
backgrounds would show variation in mitochondrial function and oxidative stress markers …
backgrounds would show variation in mitochondrial function and oxidative stress markers …
Absence of nicotinamide nucleotide transhydrogenase in C57BL/6J mice exacerbates experimental atherosclerosis
…, AW Orr, MD Woolard, DM Krzywanski - Journal of vascular …, 2018 - karger.com
Background: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and
vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (…
vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (…
A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile
…, DA Dickinson, DM Krzywanski… - … of Physiology-Lung …, 2002 - journals.physiology.org
In A549 cell culture, significant variability was found in sensitivity to actinomycin D. Using
limiting dilution, actinomycin D-susceptible (G4S) and -resistant (D3R) subclones were isolated…
limiting dilution, actinomycin D-susceptible (G4S) and -resistant (D3R) subclones were isolated…