Antiaging therapies show promise in model organism research. Translation to humans is
needed to address the challenges of an aging global population. Interventions to slow human …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms of …

Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism
in males and premature ovarian insufficiency in female carriers. FXS is also a …

Objective: Despite a prevailing assumption that adult ADHD is a childhood-onset
neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the …

The observation that animal morphology tends to be conserved during the embryonic phylotypic
period (a period of maximal similarity between the species within each animal phylum) …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell
cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-…

Background MicroRNAs (miRNAs) are short, non-coding RNA regulators of protein coding
genes. miRNAs play a very important role in diverse biological processes and various …

Crosslinking and immunoprecipitation (CLIP) protocols have made it possible to identify
transcriptome-wide RNA-protein interaction sites. In particular, PAR-CLIP utilizes a …