Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …

Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …

Mapping perturbed molecular circuits that underlie complex diseases remains a great
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific gene …

Many bioinformatics methods have been proposed for reducing the complexity of large gene
or protein networks into relevant subnetworks or modules. Yet, how such methods compare …

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to
the microenvironment of individual cells. Here we study the influence of the cell population …

Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …

Off-the-shelf routing products are often constrained by being designed to meet specific needs,
in terms of both software and hardware. Networking professionals may face problems that …

The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their
parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in …

Organismal size depends on the interplay between genetic and environmental factors.
Genome-wide association (GWA) analyses in humans have implied many genes in the control of …

Magnesium (Mg 2+) homeostasis is critical for metabolism. However, the genetic determinants
of the renal handling of Mg 2+, which is crucial for Mg 2+ homeostasis, and the potential …