BackgroundEarly worsening of anxiety, agitation and irritability are thought to be common
among people commencing antidepressants, especially for anxiety disorders. This …

This article highlights the evidence linking depression to increased inflammatory drive and
explores putative mechanisms for the association by reviewing both preclinical and clinical …

This revision of the 2005 British Association for Psychopharmacology guidelines for the
evidence-based pharmacological treatment of anxiety disorders provides an update on key …

Irregularities of serotonin function in irritable bowel syndrome (IBS) may be due to changes
in the metabolism of the serotonin precursor l-tryptophan. Dietary alteration of tryptophan …

Serotonin is involved in updating responses to changing environmental circumstances.
Optimising behaviour to maximise reward and minimise punishment may require shifting …

Background Burning mouth syndrome (BMS) is an idiopathic disease characterized by the
feeling of burning in the oral cavity. Ten per cent of patients presenting to oral medicine clinics …

Serotonin is involved in a wide range of mental capacities essential for navigating the social
world, including emotion and impulse control. Much recent work on serotonin and social …

Background.Generalized anxiety disorder (GAD) and panic disorder (PD) differ in their
biology and co-morbidities. We hypothesized that GAD but not PD symptoms at the age of 15 …

Background Responding emotionally to danger is critical for survival. Normal functioning also
requires flexible alteration of emotional responses when a threat becomes safe. Aberrant …

Aggressivity is a common problem in the management of elderly patients with dementia.
Medications currently used to diminish aggressive behaviour in dementia can have problematic …