Myc-induced T cell leukemia in transgenic zebrafish
DM Langenau, D Traver, AA Ferrando, JL Kutok… - Science, 2003 - science.org
The zebrafish is an attractive model organism for studying cancer development because of
its genetic accessibility. Here we describe the induction of clonally derived T cell acute …
its genetic accessibility. Here we describe the induction of clonally derived T cell acute …
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
DM Langenau, AA Ferrando, D Traver… - Proceedings of the …, 2004 - National Acad Sciences
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck)
promoter were used to analyze critical aspects of the immune system, including patterns of …
promoter were used to analyze critical aspects of the immune system, including patterns of …
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish
X Le, DM Langenau, MD Keefe… - Proceedings of the …, 2007 - National Acad Sciences
RAS family members are among the most frequently mutated oncogenes in human cancers.
Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced …
Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced …
[PDF][PDF] The use of zebrafish to understand immunity
For decades immunologists have relied heavily on the mouse model for their experimental
designs. With the realization of the important role innate immunity plays in orchestrating …
designs. With the realization of the important role innate immunity plays in orchestrating …
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)
…, C Khayter, D Reyon, D Dobbs, DM Langenau… - Nature …, 2011 - nature.com
Engineered zinc-finger nucleases (ZFNs) enable targeted genome modification. Here we
describe context-dependent assembly (CoDA), a platform for engineering ZFNs using only …
describe context-dependent assembly (CoDA), a platform for engineering ZFNs using only …
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature Reviews Drug Discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Myelopoiesis in the zebrafish, Danio rerio
…, BH Paw, MW Kieran, DM Langenau… - Blood, The Journal …, 2001 - ashpublications.org
Genome-wide chemical mutagenesis screens in the zebrafish(Danio rerio) have led to the
identification of novel genes affecting vertebrate erythropoiesis. In determining if this …
identification of novel genes affecting vertebrate erythropoiesis. In determining if this …
Clusters of circulating tumor cells traverse capillary-sized vessels
Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of distant
organ metastasis. However, it is currently assumed that CTC clusters are too large to pass …
organ metastasis. However, it is currently assumed that CTC clusters are too large to pass …
Effects of RAS on the genesis of embryonal rhabdomyosarcoma
DM Langenau, MD Keefe, NY Storer… - Genes & …, 2007 - genesdev.cshlp.org
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle
differentiation that can result from mutational activation of RAS family members. However…
differentiation that can result from mutational activation of RAS family members. However…
Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
DM Langenau, H Feng, S Berghmans… - Proceedings of the …, 2005 - National Acad Sciences
We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled
T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and …
T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and …