User profiles for David M. Aronoff
David M AronoffProfessor, Indiana University School of Medicine Verified email at iu.edu Cited by 13199 |
Cyclic AMP: master regulator of innate immune cell function
…, DM Aronoff, M Peters-Golden - American journal of …, 2008 - atsjournals.org
Cyclic adenosine monophosphate (cAMP) was the original “second messenger” to be
discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein–…
discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein–…
Antipyretics: mechanisms of action and clinical use in fever suppression
DM Aronoff, EG Neilson - The American journal of medicine, 2001 - Elsevier
Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations
in body temperature occur when concentrations of prostaglandin E 2 (PGE 2 ) increase …
in body temperature occur when concentrations of prostaglandin E 2 (PGE 2 ) increase …
Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
DM Aronoff, C Canetti… - The Journal of Immunology, 2004 - journals.aai.org
Prostaglandin E 2 is a potent lipid mediator of inflammation that effects changes in cell
functions through ligation of four distinct G protein-coupled receptors (E-prostanoid (EP) 1, EP2, …
functions through ligation of four distinct G protein-coupled receptors (E-prostanoid (EP) 1, EP2, …
[PDF][PDF] Fever and hypothermia in systemic inflammation: recent discoveries and revisions
… Sugimoto & M. Székely: Febrile responsiveness of vagotomized rats is suppressed even
in the absence of … Katoh & M. Negishi: The rostral raphe pallidus nucleus mediates …
in the absence of … Katoh & M. Negishi: The rostral raphe pallidus nucleus mediates …
[HTML][HTML] The influence of non-steroidal anti-inflammatory drugs on the gut microbiome
MAM Rogers, DM Aronoff - Clinical Microbiology and Infection, 2016 - Elsevier
The composition of the gut microbiome with the use of non-steroidal anti-inflammatory drugs
(NSAIDs) has not been fully characterized. Drug use within the past 30 days was …
(NSAIDs) has not been fully characterized. Drug use within the past 30 days was …
[PDF][PDF] New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H 2 …
DM Aronoff, JA Oates, O Boutaud - 2006 - deepblue.lib.umich.edu
Acetaminophen (INN, paracetamol) possesses highly selective analgesic and antipyretic
effects that result from its inhibitory actions on the synthesis of prostaglandins (PGs). PGs are …
effects that result from its inhibitory actions on the synthesis of prostaglandins (PGs). PGs are …
Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls
Antibiotic usage is the most commonly cited risk factor for hospital-acquired Clostridium
difficile infections (CDI). The increased risk is due to disruption of the indigenous microbiome …
difficile infections (CDI). The increased risk is due to disruption of the indigenous microbiome …
Epidemiology of Clostridium difficile Infection
DD DePestel, DM Aronoff - Journal of pharmacy practice, 2013 - journals.sagepub.com
… The author(s) disclosed receipt of the following financial support for the research, authorship
and/or publication of this article: David M. Aronoff was supported by the National Institutes …
and/or publication of this article: David M. Aronoff was supported by the National Institutes …
Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases
O Boutaud, DM Aronoff… - Proceedings of the …, 2002 - National Acad Sciences
Acetaminophen has antipyretic and analgesic properties yet differs from the nonsteroidal
antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little …
antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little …
Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1
cAMP has largely inhibitory effects on components of macrophage activation, yet downstream
mechanisms involved in these effects remain incompletely defined. Elevation of cAMP in …
mechanisms involved in these effects remain incompletely defined. Elevation of cAMP in …