The zebrafish is an attractive model organism for studying cancer development because of
its genetic accessibility. Here we describe the induction of clonally derived T cell acute …

Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck)
promoter were used to analyze critical aspects of the immune system, including patterns of …

RAS family members are among the most frequently mutated oncogenes in human cancers.
Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced …

For decades immunologists have relied heavily on the mouse model for their experimental
designs. With the realization of the important role innate immunity plays in orchestrating …

Engineered zinc-finger nucleases (ZFNs) enable targeted genome modification. Here we
describe context-dependent assembly (CoDA), a platform for engineering ZFNs using only …

Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Genome-wide chemical mutagenesis screens in the zebrafish(Danio rerio) have led to the
identification of novel genes affecting vertebrate erythropoiesis. In determining if this …

Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of distant
organ metastasis. However, it is currently assumed that CTC clusters are too large to pass …

Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle
differentiation that can result from mutational activation of RAS family members. However…

We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled
T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and …