User profiles for David M. Suter
David M SuterAssociate Professor at EPFL Verified email at epfl.ch Cited by 4240 |
Mammalian genes are transcribed with widely different bursting kinetics
In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods
called transcriptional bursts, interspersed by silent intervals. We describe how such bursts …
called transcriptional bursts, interspersed by silent intervals. We describe how such bursts …
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells
Imaging single fluorescent proteins in living mammalian cells is challenged by out-of-focus
fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light-…
fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light-…
[HTML][HTML] Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin
The glycoprotein IgM is the major antibody produced in the primary immune response to
antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a …
antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a …
[HTML][HTML] Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell
lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the …
lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the …
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy
Superresolution microscopy based on single-molecule centroid determination has been
widely applied to cellular imaging in recent years. However, quantitative imaging of the …
widely applied to cellular imaging in recent years. However, quantitative imaging of the …
A role for mitotic bookmarking of SOX2 in pluripotency and differentiation
Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …
Stimulus-induced modulation of transcriptional bursting in a single mammalian gene
Mammalian genes are often transcribed discontinuously as short bursts of RNA synthesis
followed by longer silent periods. However, how these “on” and “off” transitions, together with …
followed by longer silent periods. However, how these “on” and “off” transitions, together with …
Modulation of transcriptional burst frequency by histone acetylation
Many mammalian genes are transcribed during short bursts of variable frequencies and
sizes that substantially contribute to cell-to-cell variability. However, which molecular …
sizes that substantially contribute to cell-to-cell variability. However, which molecular …
[HTML][HTML] Transcription factors and DNA play hide and seek
DM Suter - Trends in cell biology, 2020 - cell.com
Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells
The transcription factors Sox1 and Pax6 are expressed sequentially during early mouse
embryonic neurogenesis. Sox1 expression starts upon formation of neuroectoderm, whereas …
embryonic neurogenesis. Sox1 expression starts upon formation of neuroectoderm, whereas …