Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …

C. elegans OSM-9 is a TRPV channel protein involved in sensory transduction and adaptation.
Here, we show that distinct sensory functions arise from different combinations of OSM-9 …

Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from
resistance to infection to progressive disease. Here we report results from a forward genetic …

The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis,
depends on its ability to invade the host, replicate, and transmit infection. At its initial …

All animals detect osmotic and mechanical stimuli, but the molecular basis for these responses
is incompletely understood. The vertebrate transient receptor potential channel vanilloid …

A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has
been elusive in part because of imperfect surrogate laboratory hosts, each with its own …

Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria.
We show here that social feeding is induced by nociceptive neurons that detect adverse or …

Pathogenic mycobacteria induce the formation of complex cellular aggregates called
granulomas that are the hallmark of tuberculosis 1 , 2 . Here we examine the development and …

Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which
are tightly organized immune cell aggregates that are the central structure of tuberculosis. …

The intestinal epithelium forms a barrier protecting the organism from microbes and other
proinflammatory stimuli. The integrity of this barrier and the proper response to infection …