A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns.
However, to date, there is no direct evidence of circadian clock dysregulation in the brains …

There are major concerns that specific agonal conditions, including coma and hypoxia, might
affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal …

Studies of gene expression abnormalities in psychiatric or neurological disorders often
involve the use of postmortem brain tissue. Compared with single-cell organisms or clonal cell …

Background Psychiatric disorders are multigenic diseases with complex etiology that
contribute significantly to human morbidity and mortality. Although clinically distinct, several …

Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever
complete suicide. Understanding predisposing factors for suicidal behaviors in high risk …

Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types
in affected brain regions. Despite this, transcriptomic analyses of the human brain have …

The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human
cortex, performing complex integrative functions. BA10 undergoes intensive adolescent …

A detailed comparison is made of volatility forecasting techniques on Australian value-weighted
indices. The techniques compared are the naive approach (historical volatility), an …

Background Adults with Down syndrome (DS) are at risk of developing dementia and cognitive
assessment is a fundamental part of the diagnostic process. Previously, we developed a …

Local democracy is under attack. By enacting what are known as" hyper preemption" laws,
state legislatures across the country have slashed cities' lawmak-ing authority, and with it, the …