User profiles for David M. Woods
David WoodsCU Anschutz Verified email at cuanschutz.edu Cited by 1390 |
HDAC inhibition upregulates PD-1 ligands in melanoma and augments immunotherapy with PD-1 blockade
Expression of PD-1 ligands by tumors and interaction with PD-1–expressing T cells in the
tumor microenvironment can result in tolerance. Therapies targeting this coinhibitory axis have …
tumor microenvironment can result in tolerance. Therapies targeting this coinhibitory axis have …
The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor …
D Briere, N Sudhakar, DM Woods, J Hallin… - Cancer Immunology …, 2018 - Springer
Checkpoint inhibitor therapy has led to major treatment advances for several cancers including
non-small cell lung cancer (NSCLC). Despite this, a significant percentage of patients do …
non-small cell lung cancer (NSCLC). Despite this, a significant percentage of patients do …
The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity
Melanoma is the deadliest skin cancer, and its incidence has been increasing faster than any
other cancer. Although immunogenic, melanoma is not effectively cleared by host immunity…
other cancer. Although immunogenic, melanoma is not effectively cleared by host immunity…
Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function
…, J Chen, SL Deng, F Cheng, A Distler, DM Woods… - Molecular …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells capable of
suppressing anti-tumor T cell function in the tumor microenvironment, represent an imposing …
suppressing anti-tumor T cell function in the tumor microenvironment, represent an imposing …
[HTML][HTML] C reactive protein impairs adaptive immunity in immune cells of patients with melanoma
…, M Krogsgaard, M Vassallo, DM Woods… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background High C reactive protein (CRP) levels have been reported to be associated with
a poor clinical outcome in a number of malignancies and with programmed cell death …
a poor clinical outcome in a number of malignancies and with programmed cell death …
[HTML][HTML] HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics
…, SN Quayle, SS Jones, JS Weber, DM Woods - … for immunotherapy of …, 2019 - Springer
Background Therapies targeting anti-tumor T-cell responses have proven successful in the
treatment of a variety of malignancies. However, as most patients still fail to respond, …
treatment of a variety of malignancies. However, as most patients still fail to respond, …
T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model
Histone acetylation and the families of enzymes responsible for controlling these epigenetic
marks have been implicated in regulating T-cell maturation and phenotype. Here, we …
marks have been implicated in regulating T-cell maturation and phenotype. Here, we …
Decreased suppression and increased phosphorylated STAT3 in regulatory T cells are associated with benefit from adjuvant PD-1 blockade in resected metastatic …
DM Woods, R Ramakrishnan, AS Laino… - Clinical Cancer …, 2018 - AACR
Purpose: PD-1 blockade induces durable responses in patients with metastatic melanoma
and prolongs relapse-free survival in patients with resected melanoma; however, current …
and prolongs relapse-free survival in patients with resected melanoma; however, current …
Association of tumor microenvironment T-cell repertoire and mutational load with clinical outcome after sequential checkpoint blockade in melanoma
…, FS Hodi, C Horak, H Chang, DM Woods… - Cancer immunology …, 2019 - AACR
To understand prognostic factors for outcome between differentially sequenced nivolumab
and ipilimumab in a randomized phase II trial, we measured T-cell infiltration and PD-L1 by …
and ipilimumab in a randomized phase II trial, we measured T-cell infiltration and PD-L1 by …
High-parameter single-cell analysis
…, WE Lomas III, AS Laino, DM Woods - Annual Review of …, 2019 - annualreviews.org
Thousands of transcripts and proteins confer function and discriminate cell types in the body.
Using high-parameter technologies, we can now measure many of these markers at once, …
Using high-parameter technologies, we can now measure many of these markers at once, …