Purpose Fresh-frozen (FF) tissue is the optimal source of DNA for whole-genome sequencing
(WGS) of cancer patients. However, it is not always available, limiting the widespread …

The inter-differentiation between cell states promotes cancer cell survival under stress and
fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience …

Cancer remains one of the leading causes of mortality worldwide, leading to increased
interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, …

Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer
patients, indicating the complexity of the tumor microenvironment. Expression of HLA-E is …

Background: Cancer patients often display dysfunctional antitumor T-cell responses. Because
noteworthy benefits of immune checkpoint pathway blockade, such as programmed cell …

Prokineticins are multifunctional secreted proteins that were originally identified as regulators
of intestinal contraction but subsequently shown to affect vascular function, hyperalgesia, …

Enrichment of CD103 + tumor-infiltrating T lymphocytes (TIL) is associated with improved
outcomes in patients. However, the characteristics of human CD103 + cytotoxic CD8 + T cells (…

The purpose of this study was to investigate the role of lipoxin A 4 , an anti‐inflammatory and
proresolution modulator, during human parturition. We measured serum levels of lipoxin A …

Prokineticins and their receptors are expressed in various cellular compartments in human
endometrium, with prokineticin 1 (PROK1) showing a dynamic pattern of expression across …

Pro-inflammatory mediators, like prostaglandin (PG) and chemokines, promote tumourigenesis
by enhancing cell proliferation, migration of immune cells and recruitment of blood …