Background Articular cartilage defects are a veritable therapeutic problem because therapeutic
options are very scarce. Due to the poor self-regeneration capacity of cartilage, minor …

Fibro-adipogenic progenitors (FAPs) are resident mesenchymal progenitors in adult skeletal
muscle that support muscle repair, but also give rise to fibrous and adipose infiltration in …

Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to
determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone …

Umbilical cord blood (UCB) is an attractive alternative to bone marrow for isolation of
mesenchymal stem cells (MSCs) to treat articular cartilage defects. Here, we set out to determine …

Cartilage healing by tissue engineering is an alternative strategy to reconstitute functional
tissue after trauma or age-related degeneration. However, chondrocytes, the major player in …

Osteoarthritis (OA) is an irreversible pathology that causes a decrease in articular cartilage
thickness, leading finally to the complete degradation of the affected joint. The low …

The existence of a link between estrogen deprivation and osteoarthritis (OA) in
postmenopausal women suggests that 17β-estradiol (17β-E 2 ) may be a modulator of cartilage …

Type II collagen is a marker of articular cartilage encoded by the COL2A1 gene. The nature
of the trans factors involved in the upregulation of this gene by insulin-like growth factor-I (IGF…

Aging is one of the major risk factors of osteoarthritis. This pathology during which chondrocytes
undergo modifications of their phenotype may result from alteration of transforming …

Pw1/Peg3 is an imprinted gene expressed from the paternally inherited allele. Several imprinted
genes, including Pw1/Peg3, have been shown to regulate overall body size and play a …