The suite of currently used drugs can be divided into two categories – traditional ‘small
molecule’ drugs with typical molecular weights of <500 Da but with oral bioavailability, and much …

Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and
CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells. …

The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis, …

Oxidative stress markers as well as high concentrations of copper are found in the vicinity of
Aβ amyloid deposits in Alzheimer's disease. The neurotoxicity of Aβ in cell culture has been …

Cu and Zn have been shown to accumulate in the brains of Alzheimer's disease patients.
We have previously reported that Cu 2+ and Zn 2+ bind amyloid β (Aβ), explaining their …

T cells discriminate between foreign and host molecules by recognizing distinct microbial
molecules, predominantly peptides and lipids 1 , 2 , 3 , 4 . Riboflavin precursors found in many …

The three-dimensional solution structure of the 40 residue amyloid β-peptide, Aβ(1−40), has
been determined using NMR spectroscopy at pH 5.1, in aqueous sodium dodecyl sulfate (…

Zn(II) and Cu(II) precipitate Aβ in vitro into insoluble aggregates that are dissolved by metal
chelators. We now report evidence that these biometals also mediate the deposition of Aβ …

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR)
α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …

Histone deacetylases (HDACs) remove an acetyl group from lysine residues of target proteins
to regulate cellular processes. Small-molecule inhibitors of HDACs cause cellular growth …