Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding
the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of …

During clathrin-mediated endocytosis, membrane scission marks the isolation of a cargo-laden
clathrin-coated pit (CCP) from the cell exterior. Here we used live-cell imaging of a pH-…

Clathrin seems to be dispensable for some endocytic processes and, in several instances,
no cytosolic coat protein complexes could be detected at sites of membrane invagination. …

Many synapses in the mature CNS are wrapped by a dense extracellular matrix (ECM). Using
single-particle tracking and fluorescence recovery after photobleaching, we found that this …

Classical cell biology teaches that exocytosis causes the membrane of exocytic vesicles to
disperse into the cell surface and that a cell must later retrieve by molecular sorting whatever …

Genetic mutations of SHANK3 have been reported in patients with intellectual disability,
autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a …

Fluorescent proteins with pH-sensitive fluorescence are valuable tools for the imaging of
exocytosis and endocytosis. The Aequorea green fluorescent protein mutant superecliptic …

Remodeling of the extracellular matrix by carcinoma cells during metastatic dissemination
requires formation of actin-based protrusions of the plasma membrane called invadopodia, …

GABA A -mediated miniature IPSCs (mIPSCs) were recorded from layer V pyramidal neurons
of the visual cortex using whole-cell patch-clamp recording in rat brain slices. At room …

Presynaptic ionotropic glutamate receptors are emerging as key players in the regulation of
synaptic transmission. Here we identify GluR7, a kainate receptor (KAR) subunit with no …