Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV consists
of a combination of PEGylated interferon-α (PEG-IFN-α) and ribavirin (RBV). To identify …

Tissue deposition of soluble proteins as amyloid fibrils underlies a range of fatal diseases.
The two naturally occurring human lysozyme variants are both amyloidogenic, and are shown …

Adolescent Adult Aged Aged, 80 and over Amyloidosis, Familial-etiology Child Child,
Preschool Colchicine-therapeutic use Epidemiologic Methods Familial Mediterranean Fever-…

Background Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes
encoding transthyretin, fibrinogen A α-chain, lysozyme, or apolipoprotein AI, is thought to …

Objective Familial cold urticaria (FCU) and Muckle‐Wells syndrome (MWS) are dominantly
inherited autoinflammatory disorders that cause rashes, fever, arthralgia, and in some …

It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is
known about what drives the differential control of the immune system in MS patients compared …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated
with demyelination and axonal loss. A whole genome association scan suggested that …

BACKGROUND & AIMS: Polymorphisms in IL28B were shown to affect clearance of hepatitis
C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of …

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the
population and is likely to be influenced by the host genetic architecture. Here we demonstrate, …

Objective: To examine the clinical features of pediatric CNS demyelination associated with
positive myelin oligodendrocyte glycoprotein (MOG) antibodies and to examine the functional …