Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Antitumoral immunity requires organized, spatially nuanced interactions between components
of the immune tumor microenvironment (iTME). Understanding this coordinated behavior …

In the original version of this article, the Figure 1 key indicated that the CARD and DED domains
of human caspases were shown in blue and green, respectively. This was incorrect. The …

Innate immune responses are vital for pathogen defense but can result in septic shock when
excessive. A key mediator of septic shock is tumor necrosis factor–α (TNFα), which is shed …

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …

iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE),
which controls shedding of TNF-α and its biological activity in vivo. TACE is a potential …

Smg1 is a PI3K-related kinase (PIKK) associated with multiple cellular functions, including
DNA damage responses, telomere maintenance, and nonsense-mediated mRNA decay (NMD…

Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal
regulator of EGF-receptor signaling and TNFα release, is rapidly and posttranslationally …

The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor
(EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, …

The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …