Neurons have a constantly high glucose demand, and unlike muscle cells they cannot
accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake …

The onset of diabetic neuropathy, a complication of diabetes mellitus, has been linked to
poor glycemic control. We tested the hypothesis that the mitogen‐activated protein kinases (…

This study used streptozotocin (STZ; 50 mg/kg ip) diabetic rats and monitored weekly thermal
and mechanical nociceptive thresholds for 8 weeks diabetes. Rats developed mechanical …

OBJECTIVE The goal of this study was to characterize glycation adducts formed in both in
vivo extracellular matrix (ECM) proteins of endoneurium from streptozotocin (STZ)-induced …

Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration in
diabetes complications. The aim of this study was to determine whether deficits in insulin-…

Aldose reductase is the first enzyme of the sorbito!(or polyol) pathway (Fig. 1). Under
physiological conditions, flux through this pathway is probably low in most tissues, but it has not …

Insulin and the insulin-like growth factors (IGFs) may directly affect the growth, development,
and maintenance of the vertebrate nervous system. Previous in vitro studies have focused …

Aberrant neurofilament phosphorylation occurs in many neurodegenerative diseases, and in
this study, two animal models of type 1 diabetes--the spontaneously diabetic BB rat and the …

OBJECTIVE—Axonal regeneration is defective in both experimental and clinical diabetic
neuropathy, contributing to loss of axonal extremities and neuronal dysfunction. The …

Aims TeleCheck-AF is a multicentre international project initiated to maintain care delivery for
patients with atrial fibrillation (AF) during COVID-19 through teleconsultations supported by …