The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …

▪ Abstract This review summarizes the clinical history and rationale for xenotransplantation;
recent progress in understanding the physiologic, immunologic, and infectious obstacles to …

Miniature swine have several advantages over other potential donor species as a xenograft
donor for clinical use. Among these advantages are: (1) unlimited availability; (2) size (…

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to
humanity. Because of its recent emergence, there is a paucity of information regarding viral …

Background and Methods Trials of antidepressant medications for smoking cessation have
had mixed results. We conducted a double-blind, placebo-controlled trial of a sustained-…

A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by
immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a …

International standardization of criteria for the histologic diagnosis of renal allograft rejection:
The Banff working classification of kidney transplant pathology. A group of renal …

<p id="p001"> <named-content content-type="exam-tint" id="tint1" xlink:href="10.1056/NEJMcme071074"
xlink:role="ONE-A ONE-B ONE-C ONE-D" xlink:type="simple">Five patients …

Langerhans cells constitute a morphologically well characterised subpopulation (3–8%) of
mammalian epidermal cells which, in contrast to the bulk of epidermal cells, bear Fc-IgG and …

Packing problems, such as how densely objects can fill a volume, are among the most
ancient and persistent problems in mathematics and science. For equal spheres, it has only …