T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the
thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency …

With several therapeutic strategies for facioscapulohumeral muscular dystrophy (FSHD)
entering clinical testing, outcome measures are becoming increasingly important. Considering …

Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA
hypomethylation, but the impact of DNA methylation loss on transcription has not been …

Background Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a
variety of eukaryotic organisms. Deletion of MORCs result in several developmental …

Background Variants in the Structural Maintenance of Chromosomes flexible Hinge Domain-containing
protein 1 (SMCHD1) can cause facioscapulohumeral muscular dystrophy type 2 (…

Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy clinically
characterized by weakness in the facial, shoulder girdle and upper a muscles. FSHD is caused by …

DNA methylation is a key epigenetic modification essential for normal development. How
particular factors control DNA methylation patterns and activity of a given locus is incompletely …

The relevance of power quality (PQ) issues has recently augmented because of the
increased use of power electronic equipment, which results in a voltage deviation and current …

Introduction Cervical cancer (CC) is the most common malignancy throughout developing
countries, although considered rare, central nervous system metastasis (CNSm) does occur. …

Currently, induction motor (IM) is the most common electric machine in the industry. IMs are
robust machines; however, they are prone to suffer failures, often located in stator winding …