Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless,
its genome still contains unannotated coding and non-coding genes, transcripts, exons …

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

Generation of the "epitranscriptome" through post-transcriptional ribonucleoside modification
embeds a layer of regulatory complexity into RNA structure and function. Here, we describe …

Background Drosophila melanogaster females have two X chromosomes and two
autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA). …

Both genome content and deployment contribute to phenotypic differences between species
1 , 2 , 3 , 4 , 5 . Sex is the most important difference between individuals in a species and …

Several contributing factors have been implicated in evolutionary rate heterogeneity among
proteins, but their evolutionary mechanisms remain poorly characterized. The recently …

Many animal species use a chromosome-based mechanism of sex determination, which has
led to the coordinate evolution of dosage-compensation systems. Dosage compensation …

mRNA function is influenced by modifications that modulate canonical nucleobase behavior.
We show that a single modification mediates distinct impacts on mRNA translation in a …

Accurate gene model annotation of reference genomes is critical for making them useful.
The modENCODE project has improved the D. melanogaster genome annotation by using …