[HTML][HTML] An epigenetic hypothesis of aging-related cognitive dysfunction
This brief review will focus on a new hypothesis for the role of epigenetic mechanisms in
aging-related disruptions of synaptic plasticity and memory. Epigenetics refers to a set of …
aging-related disruptions of synaptic plasticity and memory. Epigenetics refers to a set of …
[HTML][HTML] Regulation of histone acetylation during memory formation in the hippocampus
…, KD Brown, MA Trinh, DL Molfese, JD Sweatt - Journal of Biological …, 2004 - ASBMB
Formation of long term memory begins with the activation of many disparate signaling
pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We …
pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We …
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
…, JL Noebels, J David Sweatt… - Human molecular …, 2004 - academic.oup.com
Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2), encoding a transcriptional
repressor, cause Rett syndrome and a variety of related neurodevelopmental disorders. …
repressor, cause Rett syndrome and a variety of related neurodevelopmental disorders. …
[PDF][PDF] Covalent modification of DNA regulates memory formation
CA Miller, JD Sweatt - Neuron, 2007 - cell.com
DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases
(DNMTs). DNA methylation is associated with transcriptional silencing and has been …
(DNMTs). DNA methylation is associated with transcriptional silencing and has been …
The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
JD Sweatt - Journal of neurochemistry, 2001 - Wiley Online Library
The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies,
was originally discovered as a critical regulator of cell division and differentiation. As further …
was originally discovered as a critical regulator of cell division and differentiation. As further …
Lasting epigenetic influence of early-life adversity on the BDNF gene
BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver…
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver…
The MAPK cascade is required for mammalian associative learning
…, JC Selcher, JJ Petraitis, JM Trzaskos, JD Sweatt - Nature …, 1998 - nature.com
Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling
during mitogenesis and differentiation of mitotic cells. Recently MAPK activation in post-mitotic …
during mitogenesis and differentiation of mitotic cells. Recently MAPK activation in post-mitotic …
[HTML][HTML] A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation
JD English, JD Sweatt - Journal of Biological Chemistry, 1997 - ASBMB
The mitogen-activated protein kinase (MAPK) cascade has been intensely studied as a primary
biochemical pathway through which a variety of extracellular stimuli initiate and regulate …
biochemical pathway through which a variety of extracellular stimuli initiate and regulate …
Mitogen-activated protein kinases in synaptic plasticity and memory
JD Sweatt - Current opinion in neurobiology, 2004 - Elsevier
This review highlights five areas of recent discovery concerning the role of extracellular-signal
regulated kinases (ERKs) in the hippocampus. First, ERKs have recently been directly …
regulated kinases (ERKs) in the hippocampus. First, ERKs have recently been directly …
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
…, Y Zhou, SL Campbell, T Le, E Li, JD Sweatt… - Nature …, 2010 - nature.com
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …