[HTML][HTML] An epigenetic hypothesis of aging-related cognitive dysfunction

…, TL Roth, C Barnes, D Sweatt - Frontiers in aging …, 2010 - frontiersin.org
This brief review will focus on a new hypothesis for the role of epigenetic mechanisms in
aging-related disruptions of synaptic plasticity and memory. Epigenetics refers to a set of …

[HTML][HTML] Regulation of histone acetylation during memory formation in the hippocampus

…, KD Brown, MA Trinh, DL Molfese, JD Sweatt - Journal of Biological …, 2004 - ASBMB
Formation of long term memory begins with the activation of many disparate signaling
pathways that ultimately impinge on the cellular mechanisms regulating gene expression. We …

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice

…, JL Noebels, J David Sweatt… - Human molecular …, 2004 - academic.oup.com
Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2), encoding a transcriptional
repressor, cause Rett syndrome and a variety of related neurodevelopmental disorders. …

[PDF][PDF] Covalent modification of DNA regulates memory formation

CA Miller, JD Sweatt - Neuron, 2007 - cell.com
DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases
(DNMTs). DNA methylation is associated with transcriptional silencing and has been …

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

JD Sweatt - Journal of neurochemistry, 2001 - Wiley Online Library
The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies,
was originally discovered as a critical regulator of cell division and differentiation. As further …

Lasting epigenetic influence of early-life adversity on the BDNF gene

TL Roth, FD Lubin, AJ Funk, JD Sweatt - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Childhood maltreatment and early trauma leave lasting imprints on neural
mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver…

The MAPK cascade is required for mammalian associative learning

…, JC Selcher, JJ Petraitis, JM Trzaskos, JD Sweatt - Nature …, 1998 - nature.com
Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling
during mitogenesis and differentiation of mitotic cells. Recently MAPK activation in post-mitotic …

[HTML][HTML] A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation

JD English, JD Sweatt - Journal of Biological Chemistry, 1997 - ASBMB
The mitogen-activated protein kinase (MAPK) cascade has been intensely studied as a primary
biochemical pathway through which a variety of extracellular stimuli initiate and regulate …

Mitogen-activated protein kinases in synaptic plasticity and memory

JD Sweatt - Current opinion in neurobiology, 2004 - Elsevier
This review highlights five areas of recent discovery concerning the role of extracellular-signal
regulated kinases (ERKs) in the hippocampus. First, ERKs have recently been directly …

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

…, Y Zhou, SL Campbell, T Le, E Li, JD Sweatt… - Nature …, 2010 - nature.com
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …