One of the defining characteristics of a pre-metastatic niche, a fundamental requirement for
primary tumor metastasis, is infiltration of immunosuppressive macrophages. How these …

Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the
metastatic microenvironment. Here, we explore the implications of reprogramming pre-…

We propose a system for observing the correlated phase dynamics of two mesoscopic
ensembles of atoms through their collective coupling to an optical cavity. We find a dynamical …

SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease
called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are …

The IL-1 signaling pathway has been shown to play a critical role in the pathogenesis of
chronic, autoinflammatory skin diseases such as psoriasis. However, the exact cellular and …

Macrophages have been linked to tumor initiation, progression, metastasis, and treatment
resistance. However, the transcriptional regulation of macrophages driving the protumor …

Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

Current Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) using short-read
sequencing strategies resolve expressed Ab transcripts with limited resolution of the C region. …

Background Psoriasis recurrence is a clinically challenging issue. However, the underlying
mechanisms haven't been fully understood. Methods RNAseq analysis from affected skin of …

Despite the remarkable success of immunotherapy in many types of cancer, pancreatic
ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor …