User profiles for David U. Gorkin

David Gorkin

Emory University
Verified email at emory.edu
Cited by 7757

[HTML][HTML] Expanded encyclopaedias of DNA elements in the human and mouse genomes

…, J Halow, EL Van Nostrand, P Freese, DU Gorkin… - Nature, 2020 - nature.com
The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

[HTML][HTML] CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function

Y Guo, Q Xu, D Canzio, J Shou, J Li, DU Gorkin, I Jung… - Cell, 2015 - cell.com
CTCF and the associated cohesin complex play a central role in insulator function and
higher-order chromatin organization of mammalian genomes. Recent studies identified a …

[HTML][HTML] Multi-platform discovery of haplotype-resolved structural variation in human genomes

…, A Farrell, J Flores, T Galeev, DU Gorkin… - Nature …, 2019 - nature.com
The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

[PDF][PDF] Chromatin domains: the unit of chromosome organization

JR Dixon, DU Gorkin, B Ren - Molecular cell, 2016 - cell.com
How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics

…, S Heller, A Kleger, S Preissl, DU Gorkin… - Nature, 2021 - nature.com
Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding 1 . Translating these risk variants into mechanistic …

A method to predict the impact of regulatory variants from DNA sequence

D Lee, DU Gorkin, M Baker, BJ Strober, AL Asoni… - Nature …, 2015 - nature.com
Most variants implicated in common human disease by genome-wide association studies (GWAS)
lie in noncoding sequence intervals. Despite the suggestion that regulatory element …

[PDF][PDF] The 3D genome in transcriptional regulation and pluripotency

DU Gorkin, D Leung, B Ren - Cell stem cell, 2014 - cell.com
It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as …

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

…, R Fang, H Huang, Y Zhao, R Raviram, DU Gorkin… - Nature …, 2018 - nature.com
Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

[HTML][HTML] An atlas of dynamic chromatin landscapes in mouse fetal development

DU Gorkin, I Barozzi, Y Zhao, Y Zhang, H Huang… - Nature, 2020 - nature.com
The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource
for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental …

[HTML][HTML] A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway

C Praetorius, C Grill, SN Stacey, AM Metcalf, DU Gorkin… - Cell, 2013 - cell.com
Sequence polymorphisms linked to human diseases and phenotypes in genome-wide
association studies often affect noncoding regions. A SNP within an intron of the gene encoding …