Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

The glomerular filtration barrier, consisting of podocyte foot processes with bridging slit
diaphragm, glomerular basement membrane, and endothelium, is a key component for renal …

The glomerular filtration barrier, has historically only been spatially resolved using electron
microscopy due to the nanometer-scale dimensions of these structures. Recently, it was …

In recent years, many light-microscopy protocols have been published for visualization of
nanoscale structures in the kidney. These protocols present researchers with new tools to …

Background Diseases of the kidney’s glomerular filtration barrier are a leading cause of end
stage renal failure. Despite a growing understanding of genes involved in glomerular …

Stromal cells support epithelial cell and immune cell homeostasis and play an important role
in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response …

αKlotho (Klotho) has well established renoprotective effects; however, the molecular pathways
mediating its glomerular protection remain incompletely understood. Recent studies have …

… Author links open overlay panel Sybille Koehler 1 2 3 13 14 , Johanna Odenthal 1 2 13 ,
Vivian Ludwig 1 2 , David Unnersjö Jess 1 2 , Martin Höhne 1 2 4 , Christian Jüngst 4 , Ferdi …

Morphological alterations at the kidney filtration barrier increase intrinsic capillary wall
permeability resulting in albuminuria. However, automated, quantitative assessment of these …