User profiles for David Veesler

David Veesler

University of Washington
Verified email at uw.edu
Cited by 36157

[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein

…, YJ Park, MA Tortorici, A Wall, AT McGuire, D Veesler - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…

Broad betacoronavirus neutralization by a stem helix–specific human antibody

…, G Snell, HW Virgin, M Beltramello, D Corti, D Veesler - Science, 2021 - science.org
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …

[PDF][PDF] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion

…, M Zambon, FA Rey, D Corti, D Veesler - Cell, 2019 - cell.com
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …

[PDF][PDF] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

…, JE Bowen, MA Tortorici, AC Walls, NP King, D Veesler… - cell, 2020 - cell.com
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

…, A Lanzavecchia, MS Diamond, K Fink, D Veesler… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …

[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

…, K Fink, HW Virgin, A Lanzavecchia, D Corti, D Veesler - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …

[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

…, M Hosmillo, JH Lee, LC James, L Thukral, D Veesler… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

…, TI Croll, J Nix, HW Virgin, D Corti, G Snell, D Veesler - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …

[HTML][HTML] Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

…, HW Virgin, A Lanzavecchia, G Snell, D Veesler… - Nature, 2022 - nature.com
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …

[HTML][HTML] Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

…, JE Bowen, AC Walls, D Corti, JD Bloom, D Veesler… - Nature, 2021 - nature.com
Following its emergence in late 2019, the spread of SARS-CoV-2 1 , 2 has been tracked by
phylogenetic analysis of viral genome sequences in unprecedented detail 3 , 4 – 5 . …