User profiles for David Veesler
David VeeslerUniversity of Washington Verified email at uw.edu Cited by 36157 |
[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
[PDF][PDF] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
[PDF][PDF] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …
[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …
infection is crucial for understanding immune protection and identifying targets for …
[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
…, M Hosmillo, JH Lee, LC James, L Thukral, D Veesler… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …
concern evades antibody-mediated immunity that comes from vaccination or infection with …
[HTML][HTML] Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
[HTML][HTML] Spread of a SARS-CoV-2 variant through Europe in the summer of 2020
Following its emergence in late 2019, the spread of SARS-CoV-2 1 , 2 has been tracked by
phylogenetic analysis of viral genome sequences in unprecedented detail 3 , 4 – 5 . …
phylogenetic analysis of viral genome sequences in unprecedented detail 3 , 4 – 5 . …