Metastatic behavior of breast cancer subtypes

…, R Woods, MCU Cheang, D Voduc… - Journal of clinical …, 2010 - ascopubs.org
Purpose Prognostic and predictive factors are well established in early-stage breast cancer,
but less is known about which metastatic sites will be affected. Methods Patients with early-…

[HTML][HTML] Supervised risk predictor of breast cancer based on intrinsic subtypes

…, MCU Cheang, S Leung, D Voduc… - Journal of clinical …, 2009 - ncbi.nlm.nih.gov
Purpose To improve on current standards for breast cancer prognosis and prediction of
chemotherapy benefit by developing a risk model that incorporates the gene expression–based “…

Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer

MCU Cheang, SK Chia, D Voduc, D Gao… - JNCI: Journal of the …, 2009 - academic.oup.com
Background Gene expression profiling of breast cancer has identified two biologically
distinct estrogen receptor (ER)-positive subtypes of breast cancer: luminal A and luminal B. …

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

MCU Cheang, D Voduc, C Bajdik, S Leung… - Clinical cancer …, 2008 - AACR
Purpose: Basal-like breast cancer is associated with high grade, poor prognosis, and
younger patient age. Clinically, a triple-negative phenotype definition [estrogen receptor, …

A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor–positive breast cancer

TO Nielsen, JS Parker, S Leung, D Voduc, M Ebbert… - Clinical cancer …, 2010 - AACR
Purpose: To compare clinical, immunohistochemical (IHC), and gene expression models of
prognosis applicable to formalin-fixed, paraffin-embedded blocks in a large series of …

External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node …

…, JM Crook, FLW Wong, HM Carolan, D Voduc… - The Lancet, 2019 - thelancet.com
Background Whole breast irradiation delivered once per day over 3–5 weeks after breast
conserving surgery reduces local recurrence with good cosmetic results. Accelerated partial …

[HTML][HTML] Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases

AB Rajput, DA Turbin, MCU Cheang, DK Voduc… - Breast cancer research …, 2008 - Springer
Purpose We have previously demonstrated in a pilot study of 348 invasive breast cancers
that mast cell (MC) infiltrates within primary breast cancers are associated with a good …

Defining breast cancer intrinsic subtypes by quantitative receptor expression

…, M Martin, TO Nielsen, A Prat, D Voduc… - The …, 2015 - academic.oup.com
Purpose. To determine intrinsic breast cancer subtypes represented within categories defined
by quantitative hormone receptor (HR) and HER2 expression. Methods. We merged 1,557 …

[PDF][PDF] Identification of a low-risk luminal A breast cancer cohort that may not benefit from breast radiotherapy

FF Liu, W Shi, SJ Done, N Miller, M Pintilie, D Voduc… - J Clin …, 2015 - researchgate.net
Purpose To determine the prognostic and predictive value of intrinsic subtyping by using
immunohistochemical (IHC) biomarkers for ipsilateral breast relapse (IBR) in participants in an …

GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value

D Voduc, M Cheang, T Nielsen - Cancer Epidemiology Biomarkers & …, 2008 - AACR
Background: GATA-3 is a transcription factor involved in human growth and differentiation.
Gene expression profiling has shown that GATA-3 is highly expressed in the Luminal A …