We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Objective: To review the evidence that childhood is a period of particular susceptibility to the
carcinogenic effects of solar radiation. Methods: Studies were identified through searches of …

So far, two genes associated with familial melanoma have been identified, accounting for a
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …

Importance Despite many cases being preventable, cutaneous melanoma remains the most
serious skin cancer worldwide. Understanding the scale and profile of the disease is vital to …

New melanoma therapies are being developed rapidly, complementing prevention and
detection strategies for disease control. Estimating the future burden of melanoma is necessary …

Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Background: Some melanomas form on sun-exposed body sites, whereas others do not. We
previously proposed that melanomas at different body sites arise through different pathways …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …

Objective: To measure the relative risks of adenocarcinomas of the oesophagus and gastro-oesophageal
junction associated with measures of obesity, and their interactions with age, …

Obesity is a risk factor for several hormone-related cancers but evidence for an effect on risk
of epithelial ovarian cancer remains inconclusive. Many studies evaluating this association …