Neovascularization and increased glycolysis, two universal characteristics of solid tumors,
represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion, …

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group
of tumours about which little is known biologically, and whose diagnosis, on the basis of …

Ependymal tumors across age groups are currently classified and graded solely by histopathology.
It is, however, commonly accepted that this classification scheme has limited clinical …

Id proteins may control cell differentiation by interfering with DNA binding of transcription
factors. Here we show that targeted disruption of the dominant negative helix–loop–helix …

BACKGROUND AND PURPOSE: Sensitivity, positive predictive value (PPV), and negative
predictive value (NPV) of conventional MR imaging in predicting glioma grade are not high. …

BACKGROUND Hypoxia inducible factor‐1 (HIF‐1) plays a critical role in angiogenesis
during vascular development. The authors tested the hypothesis that HIF‐1 expression …

Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of
children, with no effective treatment and near 100% fatality. The failure of most therapies can …

PURPOSE: To evaluate the role of T2*-weighted echo-planar perfusion imaging by using a
first-pass gadopentetate dimeglumine technique to determine the association of magnetic …

Dynamic contrast agent–enhanced perfusion magnetic resonance (MR) imaging provides
physiologic information that complements the anatomic information available with …

The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human
cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors …