User profiles for Davide Mangani
Davide ManganiInstitute for Research in Biomedicine Verified email at irb.usi.ch Cited by 532 |
[PDF][PDF] Endogenous glucocorticoid signaling regulates CD8+ T cell differentiation and development of dysfunction in the tumor microenvironment
Identifying signals in the tumor microenvironment (TME) that shape CD8 + T cell phenotype
can inform novel therapeutic approaches for cancer. Here, we identified a gradient of …
can inform novel therapeutic approaches for cancer. Here, we identified a gradient of …
T cell factor 1: A master regulator of the T cell response in disease
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of T …
development and T memory formation and encompasses new functions in the regulation of T …
[HTML][HTML] MiR-221/222 target the DNA methyltransferase MGMT in glioma cells
Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best
clinical approach for treatment is based on administration of temozolomide (TMZ) in …
clinical approach for treatment is based on administration of temozolomide (TMZ) in …
Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy
Stem-like CD8 + T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
The network of immunosuppressive pathways in glioblastoma
D Mangani, M Weller, P Roth - Biochemical pharmacology, 2017 - Elsevier
Glioblastoma remains a fatal tumor despite increased knowledge regarding the complex
signalling pathways that drive this devastating disease. Recently, immunotherapeutic …
signalling pathways that drive this devastating disease. Recently, immunotherapeutic …
Learning from the nexus of autoimmunity and cancer
D Mangani, D Yang, AC Anderson - Immunity, 2023 - cell.com
The immune system plays critical roles in both autoimmunity and cancer, diseases at opposite
ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against …
ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against …
[HTML][HTML] PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic
cells (DC) interact with the gut microbiome and antigens and are important in maintaining …
cells (DC) interact with the gut microbiome and antigens and are important in maintaining …
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19
T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection and play a major role in disease outcome and long-lasting immunity. …
infection and play a major role in disease outcome and long-lasting immunity. …
Limited role for transforming growth factor–β pathway activation-mediated escape from VEGF inhibition in murine glioma models
D Mangani, M Weller, E Seyed Sadr… - Neuro …, 2016 - academic.oup.com
Background The vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)–β
pathways regulate key biological features of glioblastoma. Here we explore whether …
pathways regulate key biological features of glioblastoma. Here we explore whether …
[HTML][HTML] Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling
Gut inflammation involves contributions from immune and non-immune cells, whose
interactions are shaped by the spatial organization of the healthy gut and its remodeling during …
interactions are shaped by the spatial organization of the healthy gut and its remodeling during …