User profiles for Davide Mangani

Davide Mangani

Institute for Research in Biomedicine
Verified email at irb.usi.ch
Cited by 532

[PDF][PDF] Endogenous glucocorticoid signaling regulates CD8+ T cell differentiation and development of dysfunction in the tumor microenvironment

…, M Ferreira, KO Dixon, G Fell, K Tooley, D Mangani… - Immunity, 2020 - cell.com
Identifying signals in the tumor microenvironment (TME) that shape CD8 + T cell phenotype
can inform novel therapeutic approaches for cancer. Here, we identified a gradient of …

T cell factor 1: A master regulator of the T cell response in disease

G Escobar, D Mangani, AC Anderson - Science immunology, 2020 - science.org
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of T …

[HTML][HTML] MiR-221/222 target the DNA methyltransferase MGMT in glioma cells

C Quintavalle, D Mangani, G Roscigno, G Romano… - PloS one, 2013 - journals.plos.org
Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best
clinical approach for treatment is based on administration of temozolomide (TMZ) in …

Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy

…, C Edwards, E Froimchuk, C Xue, D Mangani… - Cancer cell, 2023 - cell.com
Stem-like CD8 + T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …

The network of immunosuppressive pathways in glioblastoma

D Mangani, M Weller, P Roth - Biochemical pharmacology, 2017 - Elsevier
Glioblastoma remains a fatal tumor despite increased knowledge regarding the complex
signalling pathways that drive this devastating disease. Recently, immunotherapeutic …

Learning from the nexus of autoimmunity and cancer

D Mangani, D Yang, AC Anderson - Immunity, 2023 - cell.com
The immune system plays critical roles in both autoimmunity and cancer, diseases at opposite
ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against …

[HTML][HTML] PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

TG Moreira, D Mangani, LM Cox, J Leibowitz… - Nature …, 2021 - nature.com
The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic
cells (DC) interact with the gut microbiome and antigens and are important in maintaining …

Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19

…, A Paul, KTF Matos, D Mangani… - Proceedings of the …, 2023 - National Acad Sciences
T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection and play a major role in disease outcome and long-lasting immunity. …

Limited role for transforming growth factor–β pathway activation-mediated escape from VEGF inhibition in murine glioma models

D Mangani, M Weller, E Seyed Sadr… - Neuro …, 2016 - academic.oup.com
Background The vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)–β
pathways regulate key biological features of glioblastoma. Here we explore whether …

[HTML][HTML] Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

P Cadinu, KN Sivanathan, A Misra, RJ Xu, D Mangani… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Gut inflammation involves contributions from immune and non-immune cells, whose
interactions are shaped by the spatial organization of the healthy gut and its remodeling during …