User profiles for Davis Kuchaka
 | Davis J. KuchakaResearch Scientist, Kilimanjaro Clinical Research Institute Verified email at kcri.ac.tz Cited by 407 |
Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis molecular bacterial load assay
In this comparative biomarker study, we analysed 1768 serial sputum samples from 178
patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load …
patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load …
[HTML][HTML] Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6
There is a need for an improved vaccine for tuberculosis. ESAT-6 is a cardinal vaccine
antigen with unique properties and is included in several vaccine candidates in development. …
antigen with unique properties and is included in several vaccine candidates in development. …
Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings
The World Health Organization's 2035 vision is to reduce tuberculosis (TB) associated
mortality by 95%. While low-burden, well-equipped industrialised economies can expect to see …
mortality by 95%. While low-burden, well-equipped industrialised economies can expect to see …
Tuberculosis molecular bacterial load assay reveals early delayed bacterial killing in patients with relapse
Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients
achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria …
achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria …
Unlocking the health system barriers to maximise the uptake and utilisation of molecular diagnostics in low-income and middle-income country setting
Background Early access to diagnosis is crucial for effective management of any disease
including tuberculosis (TB). We investigated the barriers and opportunities to maximise uptake …
including tuberculosis (TB). We investigated the barriers and opportunities to maximise uptake …
[PDF][PDF] Nanopore sequencing technology for clinical diagnosis of infectious diseases where laboratory capacity is meager: A case report
…, M Shayo, M van Zwetslaar, J Njau, DJ Kuchaka… - Heliyon, 2023 - cell.com
In resource-limited settings, patients are often first presented to clinical settings when
seriously ill and access to proper clinical microbial diagnostics is often very limited or non-existing. …
seriously ill and access to proper clinical microbial diagnostics is often very limited or non-existing. …
Molecular bacterial load assay: a fast and accurate means for monitoring tuberculosis treatment response
Background Tuberculosis is a difficult disease to treat. We report a multi-centre performance
evaluation of the molecular bacterial load assay (MBLA) that monitors change in patient …
evaluation of the molecular bacterial load assay (MBLA) that monitors change in patient …
PA-583 Revolutionising tuberculosis treatment response monitoring and developing research capacity in Africa: progress and potential of the tuberculosis molecular …
…, P Mbelele, K Azam, NE Ntinginya, D Kuchaka… - 2023 - gh.bmj.com
Background Tuberculosis (TB) treatment is long and complex. Here we summarise data from
EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as …
EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as …
Improving diagnosis and monitoring of treatment response in pulmonary tuberculosis using the molecular bacterial load assay (MBLA)
Objectives Better outcomes in tuberculosis require new diagnostic and treatment monitoring
tools. In this paper we evaluated the utility of a marker of M. tuberculosis viable count, the …
tools. In this paper we evaluated the utility of a marker of M. tuberculosis viable count, the …
[HTML][HTML] Boosting effect of IL-7 in interferon gamma release assays to diagnose Mycobacterium tuberculosis infection
Background A quarter of the world’s population is estimated to be infected with Myobacterium
tuberculosis (Mtb). Infection is detected by immune response to M. tuberculosis antigens …
tuberculosis (Mtb). Infection is detected by immune response to M. tuberculosis antigens …