Multivalent protein-protein and protein-RNA interactions are the drivers of biological phase
separation. Biomolecular condensates typically contain a dense network of multiple proteins …

Histone tails are highly flexible N- or C-terminal protrusions of histone proteins which facilitate
the compaction of DNA into dense superstructures known as chromatin. On a molecular …

Liquid-liquid phase separation of multivalent proteins and RNAs drives the formation of
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …

Liquid−liquid phase separation of multivalent intrinsically disordered protein−RNA complexes
is ubiquitous in both natural and biomimetic systems. So far, isotropic liquid droplets are …

The nucleus of a eukaryotic cell is a nonequilibrium system where chromatin is subjected to
active processes that continuously rearrange it over the cell’s life cycle. Tracking the motion …

The growing interest in the DNA‐based mesoscale systems of biological and nonbiological
nature has encouraged the computational molecular science community to develop coarse‐…

Genetic switches based on the N F - κ B / I κ B / D N A system are master regulators of an
array of cellular responses. Recent kinetic experiments have shown that I κ B can actively …

Intrinsically disordered proteins (IDP) are a broad class of proteins with relatively flat energy
landscapes showing a high level of functional promiscuity, which are frequently regulated …

Histone tails, the intrinsically disordered terminal regions of histone proteins, are key modulators
of the structure and dynamics of chromatin and, consequently, are central to many DNA …

Proteomic studies have shown that cellular condensates are frequently enriched in diverse
RNA molecules, which is suggestive of mechanistic links between phase separation and …