Organ-on-a-chip devices, also known as microphysiological systems, have gained significant
attention in recent years. Recent advances in tissue engineering and microfabrication …

Despite the complexity and structural sophistication that 3D organoid models provide, their
lack of vascularization and perfusion limit the capability of these models to recapitulate organ …

The gastrointestinal tract is the site of most drug delivery and therapeutic interventions for
the management and treatment of numerous diseases. However, selective access to its …

Organ-on-a-chip systems that recapitulate tissue-level functions have been proposed to
improve in vitro–in vivo correlation in drug development. Significant progress has been made to …

Three-dimensional (3D) tissue models such as epithelial spheroids or organoids have
become popular for pre-clinical drug studies. In contrast to 2D monolayer culture, the …

Vasculature is a key component of many biological tissues and helps to regulate a wide
range of biological processes. Modeling vascular networks or the vascular interface in organ-on-…

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that
is limited in its ability to be administered in a soluble form. A library of polyester materials …

The direction and pattern of fluid flow affect vascular structure and function, in which vessel‐lining
endothelial cells exhibit variable cellular morphologies and vessel remodeling by …

Stent grafts are medical devices used to treat abdominal aortic aneurysms (AAAs) in
endovascular aneurysm repair (EVAR). Computational and experimental models have been …

… As the dawn phenomenon is characterized by glucose … dawn phenomenon in patients with
T2D. In this study, we investigated the association between glucose excursions and the dawn …