The proteome of any system is a dynamic entity, such that the intracellular concentration of
a protein is dictated by the relative rates of synthesis and degradation. In this work, we have …

The ligand-dependent degradation of activated tyrosine kinase receptors provides a means
by which mitogenic signalling can be attenuated. In many cell types the ligand-dependent …

The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease and
cytotoxic chemotherapy is the standard of care treatment for patients with advanced disease. …

Background Ejaculates contain a diverse mixture of sperm and seminal fluid proteins, the
combination of which is crucial to male reproductive success under competitive conditions. …

The ubiquitously expressed major Ras isoforms: H-, K-and N-Ras, are highly conserved, yet
exhibit different biological outputs. We have compared the relative efficiencies with which …

Defining intracellular protein concentration is critical in molecular systems biology. Although
strategies for determining relative protein changes are available, defining robust absolute …

Oncogenic mutations of Ras at codons 12, 13, or 61, that render the protein constitutively
active, are found in ∼16% of all cancer cases. Among the three major Ras isoforms, KRAS is …

Proteasomal activity is required for Met receptor degradation after acute stimulation with
hepatocyte growth factor (HGF). Inhibition of proteasomal activity with lactacystin leads to a …

Uveal melanoma (UM), the most common primary intraocular tumour in adults, is characterised
by a high frequency of metastases to the liver, typically with a fatal outcome. Proteins …