… BP P is not corrected for the fraction of ligand that is bound to plasma proteins (f P ), that is,
BP P equals the product of BP F and f P BP ND is not corrected for the free fraction of ligand in …

In postmortem studies of patients with schizophrenia, D 2 dopamine receptors in the basal
ganglia have been observed to be more numerous than in patients with no history of …

D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human
subjects by positron emission tomography after intravenous injection of 11 C-labeled 3-N-…

Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states.
The ligand 3-N-[ 11 C]methylspiperone, which preferentially binds to dopamine receptors in …

Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse.
In animals, methamphetamine and related drugs are known to damage brain dopamine (…

Importance Older adults commonly report disturbed sleep, and recent studies in humans
and animals suggest links between sleep and Alzheimer disease biomarkers. Studies are …

Importance Midlife vascular risk factors have been associated with late-life dementia. Whether
these risk factors directly contribute to brain amyloid deposition is less well understood. …

Context Blood-based analytes may be indicators of pathological processes in Alzheimer
disease (AD). Objective To identify plasma proteins associated with AD pathology using a …

Aripiprazole (OPC 14597) is an antipsychotic drug that has high affinity for dopamine D 2
and D 3 receptors and the dopamine autoreceptor. It is being developed for treatment of …

BACKGROUND: Sex differences in addictive disorders have been described. Preclinical
studies have implicated the striatal dopamine system in these differences, but human studies …