Whole genome duplication (WGD) is a dramatic evolutionary event generating many new
genes and which may play a role in survival through mass extinctions. Paddlefish and …

How can we best learn the history of a protein’s evolution? Ideally, a model of sequence
evolution should capture both the process that generates genetic variation and the functional …

This thesis is concerned with exploring the use of machine learning in comparison to traditional
linear methods for the genomic prediction of complex traits. Special attention is paid to …

Background Gene conversion of duplicated genes can slow the divergence of paralogous
copies over time but can also result in other interesting evolutionary patterns. Islands of …

… O'Casey's manuscript materials throughout and from Eileen O'Casey's letters are by kind
permission of the Estate of Seán O'Casey, while quotations from Breon O'Casey's letters are by …

Purpose All patients living with cancer, including those with metastatic cancer, are encouraged
to be physically active. This paper examines the secondary endpoints of an aerobic …

Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of
cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the …

Background: Globally, prostate cancer (PrCa) is the fourth most common cancer type. Obesity
and inflammation have been shown to play significant roles in PrCa disease progression. …

Discussion Cluster A comprised 13 isolates from individual residents of 7 nursing homes (5
isolates-NH2; 3 isolates-NH3; single isolates from NH4, NH5, NH10, NH15, and NH24). All …

Background Prostate cancer (PrCa) is the second most common cancer in Ireland. Many
men present with locally advanced or metastatic cancer for whom curative surgery is …