User profiles for Debalina Datta
 | Debalina DattaIndian Institute of Technology Bombay Verified email at iitb.ac.in Cited by 696 |
α-Synuclein aggregation nucleates through liquid–liquid phase separation
α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with Parkinson’s
disease pathogenesis. However, the early events involved in this process remain unclear. …
disease pathogenesis. However, the early events involved in this process remain unclear. …
[HTML][HTML] Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
Prion-like p53 amyloids in cancer
The global transcription factor, p53, is a master regulator of gene expression in cells.
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …
Mutations in the TP53 gene promote unregulated cell growth through the inactivation of …
Comparison of kinetics, toxicity, oligomer formation, and membrane binding capacity of α-synuclein familial mutations at the A53 site, including the newly discovered …
The involvement of α-synuclein (α-Syn) amyloid formation in Parkinson’s disease (PD)
pathogenesis is supported by the discovery of α-Syn gene (SNCA) mutations linked with familial …
pathogenesis is supported by the discovery of α-Syn gene (SNCA) mutations linked with familial …
Association of quality of life of urban elderly with socio-demographic factors.
D Datta, PP Datta, KK Majumdar - International Journal of …, 2015 - search.ebscohost.com
Introduction: Quality of life (QOL) of elderly often deteriorates due to many factors. This study
was planned to find out the different domains of QOL of elderly people affected by socio-…
was planned to find out the different domains of QOL of elderly people affected by socio-…
Direct evidence of cellular transformation by prion-like p53 amyloid infection
Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation
and amyloid formation of p53 is also implicated in cancer pathogenesis, but direct …
and amyloid formation of p53 is also implicated in cancer pathogenesis, but direct …
Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological mechanism for
sequestering macromolecules (such as proteins and nucleic acids) into membraneless …
sequestering macromolecules (such as proteins and nucleic acids) into membraneless …
Amyloid fibril-based thixotropic hydrogels for modeling of tumor spheroids in vitro
Biomaterials mimicking extracellular matrices (ECM) for three-dimensional (3D) cultures
have gained immense interest in tumor modeling and in vitro organ development. Here, we …
have gained immense interest in tumor modeling and in vitro organ development. Here, we …
Multisystem inflammatory syndrome in infants< 12 months of age, United States, May 2020–January 2021
…, LE Sosa, K Ngamsnga, A Garcia, D Datta… - The Pediatric …, 2021 - journals.lww.com
Background: Multisystem inflammatory syndrome in children (MIS-C), temporally associated
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified in …
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified in …
Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids
Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid
aggregation are well evident in various neurological disorders including Alzheimer’s disease…
aggregation are well evident in various neurological disorders including Alzheimer’s disease…