Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …

Observational epidemiological studies suffer from many potential biases, from confounding
and from reverse causation, and this limits their ability to robustly identify causal associations…

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational
prospective observational study investigating influences on health and development across the …

This glossary presents a comprehensive list of indicators of socioeconomic position used in
health research. A description of what they intend to measure is given together with how …

Worldwide prevalence of childhood obesity has increased greatly during the past three
decades. The increasing occurrence in children of disorders such as type 2 diabetes is believed …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand
how genetic and environmental characteristics influence health and development in …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …

Background Depression is a common and important cause of morbidity and mortality worldwide.
Depression is commonly treated with antidepressants and/or psychological therapy, but …