Background: Single-stranded DNA aptamers are oligonucleotides of ≈50 base pairs in
length selected for their ability to bind proteins with high specificity and affinity. Emerging DNA …

Improvements in metabolite-profiling techniques are providing increased breadth of
coverage of the human metabolome and may highlight biomarkers and pathways in common …

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly
understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-…

Importance African American individuals have disproportionate rates of coronary heart
disease (CHD) but lower levels of coronary artery calcium (CAC), a marker of subclinical CHD, …

Background: We used a large-scale, high-throughput DNA aptamer-based discovery
proteomic platform to identify circulating biomarkers of cardiac remodeling and incident heart …

High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used
increasingly in human studies. However, direct analyses to address the relative strengths …

The mechanism by which chronic thromboembolic pulmonary hypertension (CTEPH) develops
after acute pulmonary thromboembolism is unknown. We previously reported that fibrin …

Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify
large numbers of proteins efficiently and cost‐effectively and are rapidly growing in popularity. …

Integrating genetic information with metabolomics has provided new insights into genes
affecting human metabolism. However, gene-metabolite integration has been primarily studied …

Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …