PU.1 is a member of the ets family of transcription factors and is expressed exclusively in cells
of the hematopoietic lineage. Mice homozygous for a disruption in the PU.1 DNA binding …

Originally identified by their unusual ability to bind guanosine monophosphate (GMP) nucleotide
agarose, the guanylate-binding proteins (GBPs) were used extensively to promote our …

The guanylate-binding proteins (GBPs) were among the first interferon (IFN)-stimulated genes
(ISGs) discovered, but until recently, little was known about their functions and even less …

Cadherins are a family of cell adhesion molecules that exhibit calcium-dependent, homophilic
binding. Their function depends on both an HisAlaVal sequence in the first extracellular …

Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid‐modified
proteins in murine macrophages, the most dramatic being the expression of a prenyl …

The interferon-induced double-stranded RNA-activated protein kinase PKR is the prototype
of a class of double-stranded (dsRNA)-binding proteins (DRBPs) which share a dsRNA-…

To investigate the function of mGBP-2, a member of the interferon (IFN)-induced guanylate-binding
protein family of GTPases, NIH 3T3 fibroblasts were generated that constitutively …

The guanylate-binding proteins (GBPs) are a family of 65-67-kDa proteins induced by both
type I and type II interferons (IFN). Members of the GBP family of GTPases are among the …

The guanylate-binding proteins (GBPs) were first identified in the late 1970s, and within a
short period of time, investigators were aware that GBPs possessed unique properties, in …

Exposure of cells to certain cytokines can alter how these same cells respond to later cues
from other agents, such as extracellular matrix or growth factors. Interferon (IFN)-γ pre-…