Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

Increased uterine contractility at term and preterm results first from activation and then
stimulation of the myometrium. Activation can be provoked by mechanical stretch of the uterus, …

Objective: The objective of this study was to determine the influence of birth weight and
postnatal weight gain on age at menarche. Design, Setting, and Participants: This was a …

Our aim was to determine the postnatal effects of single and repeated glucocorticoid injections
during late gestation. Repeated (104, 111, 118, 125 days) or single (104 days) injections …

Microbial colonization of the human intestine impacts host metabolism and immunity;
however, exactly when colonization occurs is unclear. Although many studies have reported …

Shifts in the maternal gut microbiome have been implicated in metabolic adaptations to
pregnancy. We investigated how pregnancy and diet interact to influence the composition of the …

The association between an adverse early life environment and increased susceptibility to
later-life metabolic disorders such as obesity, type 2 diabetes and cardiovascular disease is …

An adverse early-life environment is associated with long-term disease consequences.
Adversity early in life is hypothesized to elicit developmental adaptations that serve to improve …

Background While prepubertal nutritional influences appear to play a role in sexual maturation,
there is a need to clarify the potential contributions of maternal and childhood influences …

Chronic disease risk is inextricably linked to our early-life environment, where maternal, fetal,
and childhood factors predict disease risk later in life. Currently, maternal obesity is a key …